Journal of Zhejiang University SCIENCE
(ISSN 1009-3095, Monthly)
2002   Vol. 3   No. 5   p.627-631

Study on the serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with Helicobacter pylori Infection

WU Qin-dong(吴勤动)(Department of Gastroenterology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China)  
ZHU Yong-liang(朱永良)(Department of Gastroenterology, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, China)  
SHI Yi-hai(石益海)(Department of Gastroenterology,The First Hospital of Daqing, Daqing 163001, China)  

Abstract:Objective: To evaluate the interaction between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and Helicobacter pylori (H. pylori) infection in patients with chronic gastritis and peptic ulcer. Methods: The serum levels of sICAM-1 in 205 patients with chronic gastric diseases were detected by ELISA method and the status of H. pylori was determined by histologic examination, RUT, 14C - UBT, and serology. The sera obtained from 18 healthy volunteers served as controls. Results: The serum levels of sICAM-1 were significantly higher in patients with H. pylori positive than those of H. pylori negative (889.43±32.52 ng/ml vs. 747.07±30.45 ng/ml, P<0.05). The serum levels of sICAM-1 in patients with mild, moderate and severe infection of H. pylori were 841.68±72.36 ng/ml, 905.43±37.59 ng/ml and 1012.54±49.34 ng/ml,respectively (P<0.05). The serum levels of sICAM-1 proved to be significantly correlated with the density of H. pylori colonization in gastric mucosa (rs =0.316, P<0.001). The serum levels of sICAM-1 in patients with chronic gastritis and peptic ulcer were significantly higher than those in healthy controls (P<0.05). Conclusions: These results indicated that H. pylori infection up-regulates the expression of sICAM-1.
Keywords:Helicobacter pylori, sICAM-1, Serum, Enzyme-linked immunosorbent assay (ELISA)

CLC Number:R573.3  Document ID:A

Author Resume:WU Qin-dong(吴勤动),E-mail: wuqingdon@hzcnc.com

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Manuscript Received:2002 Jan. 8

Manuscript Revised:2002 July 21

Published:2002 Dec. 1