Journal of Zhejiang University SCIENCE
(ISSN 1009-3095, Monthly)

2005   Vol. 6B   No. 1   p.49-52

Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: Neopterin and Interleukin-2

YAN Min^*, CHEN Gang, FANG Ling-ling, LIU Zi-ming, ZHANG Xiu-lai

(¹Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China)
^*E-mail: yanminnina@hotmail.com
Received July 29, 2004; revision accepted Aug. 18, 2004

Abstract: Objective: To estimate the impact of autologous transfusion on the status of perioperative immune activation in malignant tumor patients. The Serum Neopterin and Interleukin-2 (IL-2) were measured. Methods: Sixty patients undergoing elective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups: (1) Group A received autologous transfusion. (2) Group H received allogeneic transfusion. The perioperative course (Before induction of anesthesia, after operation and 5 d after operation) of Neopterin and IL-2 was compared. Results: In group A, Serum Neopterin was significantly lower than baseline after operation and IL-2 had no significant changes. In group H, both Serum Neopterin and IL-2 were significantly lower than baseline after operation and 5 d after operation. Compared with group A, Serum Neopterin was significantly lower than baseline after operation and 5 d after operation and IL-2 was significantly lower than baseline 5 d after operation. Conclusion: Autologous transfusion decreased the perioperative immune suppression in malignant stomach tumor patients.

Key words: Autologous transfusion, Allogeneic transfusion, Serum Neopterin, INF-gamma, Immunologic change
doi:10.1631/jzus.2005.B0049             CLC number: R614.1