Journal of Zhejiang University SCIENCE A
ISSN 1009-3095(Print), 1862-1775(Online), Monthly

2007   Vol. 8   No. 2   p. 323~330

On-line Access Date:   Feb. 1, 2007
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A remote control training system for rat navigation in complicated environment

FENG Zhou-yan†1,2, CHEN Wei-dong†‡1,3, YE Xue-song1,2, ZHANG Shao-min1,2, ZHENG Xiao-jing1,2, WANG Peng1,2, JIANG Jun1,3, JIN Lin1,3, XU Zhi-jian1,3, LIU Chun-qing1,4, LIU Fu-xin1,4, LUO Jian-hong1,4, ZHUANG Yue-ting†‡1,3, ZHENG Xiao-xiang†‡1,2

(1Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China)
(2College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China)
(3College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China)
(4School of Medicine, Zhejiang University, Hangzhou 310006, China)
Corresponding Author
E-mail: xufeng@hzcnc.com; chenwd@zju.edu.cn; yzhuang@cs.zju.edu.cn; zxx@mail.bme.zju.edu.cn
Received Nov. 1, 2006 revision accepted Dec. 25, 2006

Abstract: A remote control system has been developed to deliver stimuli into the rat brain through a wireless micro-stimulator for animal behavior training. The system consists of the following main components: an integrated PC control program, a transmitter and a receiver based on Bluetooth (BT) modules, a stimulator controlled by C8051 microprocessor, as well as an operant chamber and an eight-arm radial maze. The micro-stimulator is featured with its changeable amplitude of pulse output for both constant-voltage and constant-current mode, which provides an easy way to set the proper suitable stimulation intensity for different training. The system has been used in behavior experiments for monitoring and recording bar-pressing in the operant chamber, controlling rat roaming in the eight-arm maze, as well as navigating rats through a 3D obstacle route. The results indicated that the system worked stably and that the stimulation was effective for different types of rat behavior controls. In addition, the results showed that stimulation in the whisker barrel region of rat primary somatosensory cortex (SI) acted like a cue. The animals can be trained to take different desired turns upon the association between the SI cue stimulation and the reward stimulation in the medial forebrain bundle (MFB).

Key words: Remote control, Brain, Navigation, Stimulator, Reward stimulation, Whisker
doi:10.1631/jzus.2007.A0323             CLC number: R338; TP8

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