Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2007   Vol. 8   No. 9   p. 609~611

Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment^#

DIMITROV Borislav D.^†1, ATANASSOVA Penka A.², RACHKOVA Mariana I.³

(¹BORDANI, Alzano Lombardo, Bergamo 24022, Italy)
(²Department of Neurology, Medical University, Plovdiv 4000, Bulgaria)
(³ASSON-93 Research Co., Chicago, IL 60056, USA)
^†E-mail: bdd11@yahoo.com
Received Aug. 2, 2007 revision accepted Aug. 10, 2007

Abstract: This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.

Key words: Melanoma, Brain metastases, Neural stem/progenitor cells (NSPCs), Cytosine deaminase
doi:10.1631/jzus.2007.B0609             CLC number: R74

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