Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2010   Vol. 11   No. 1   p. 22~26

On-line Access Date:   Jan. 1, 2010
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Pancreatic somatostatinoma with obscure inhibitory syndrome and mixed pathological pattern

Bo ZHANG1, Qiu-ping XIE1, Shun-liang GAO1, Yan-biao FU2, Yu-lian WU†‡1

(1Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China)
(2Department of Pathology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China)
Corresponding Author
E-mail: wuyulian@medmail.com.cn
Received June 12, 2009; revision accepted Oct. 13, 2009; Crosschecked Dec. 2, 2009

Abstract: Somatostatinoma is a very rare neuroendocrine tumor that originates from D cells and accounts for less than 1% of all gastrointestinal endocrine tumors. The duodenum is the most frequent site for this tumor, followed by the pancreas. We here describe a 46-year-old Chinese woman who developed pancreatic somatostatinoma presenting with the characteristic “inhibitory” syndrome, but the symptoms were obscure and seemingly uncorrelated. This case is also unique for its large tumor size and mixed pathological pattern. Distal pancreatectomy was performed, and the patient has remained well since operation. As the syndromes of somatostatinoma may be obscure and atypical, clinicians should review all clinical findings to obtain an accurate diagnosis. Aggressive surgery is preferred to improve the survival.

Key words: Neuroendocrine tumor, Somatostatinoma, Somatostatinoma syndrome, Pancreatic hormone-producing tumor, Pancreatectomy
doi:10.1631/jzus.B0900166             CLC number: R73

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