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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.11 P.1045~1056

10.1631/jzus.2005.B1045


Acute phase reaction and acute phase proteins


Author(s):  GRUYS E., TOUSSAINT M.J.M., NIEWOLD T.A., KOOPMANS S.J.

Affiliation(s):  Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands; more

Corresponding email(s):   e.gruys@vet.uu.nl

Key Words:  Acute phase protein, Acute phase reaction, Animal health, Assessment, Cytokine, Index, Nutrition


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GRUYS E., TOUSSAINT M.J.M., NIEWOLD T.A., KOOPMANS S.J.. Acute phase reaction and acute phase proteins[J]. Journal of Zhejiang University Science B, 2005, 6(1): 1045~1056.

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Abstract: 
A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given. It appears that APPs represent appropriate analytes for assessment of animal health. Whereas they represent non-specific markers as biological effect reactants, they can be used for assessing nutritional deficits and reactive processes, especially when positive and negative acute phase variables are combined in an index. When such acute phase index is applied to separate healthy animals from animals with some disease, much better results are obtained than with single analytes and statistically acceptable results for culling individual animals may be reached. Unfortunately at present no cheap, comprehensive and easy to use system is available for assessing various acute phase proteins in serum or blood samples at the same time. Protein microarray or fluid phase microchip technology may satisfy this need; and permit simultaneous analysis of numerous analytes in the same small volume sample and enable integration of information derived from systemic reactivity and nutrition with disease specific variables. Applying such technology may help to solve health problems in various countries not only in animal husbandry but also in human populations.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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Open peer comments: Debate/Discuss/Question/Opinion

<1>

göksel@bayramli<gbayramli@yahoo.com>

2014-09-01 18:42:54

for my phd thesis

Annita@Unesp<annitamgirardi@gmail.com>

2014-04-09 03:21:27

I need to know more about this subject.

gehad@No address<gehad.donia@yahoo.com>

2013-02-21 16:44:45

iam interesting by this subject

Shahram@UMSU<shahabirabori@gmail.com>

2011-05-04 03:23:18

Useful paper

Dike@student<dike\_28@yahoo.co.id>

2010-12-24 18:31:14

GREAT

Shamil@KAN<stazhibayev@kan-kaz.org>

2010-12-24 16:20:38

Useful article

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