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Received: 2005-11-22

Revision Accepted: 2005-12-26

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.2 P.162~163

doi: 10.1631/jzus.2006.B0162


Clinical cytogenetics and molecular cytogenetics


Author(s):  Li Marilyn, Pinkel Daniel

Affiliation(s):  1.Medical School, Tulane University, New Orleans, LA 70112-2699, USA; Laboratory of Medicine, University of California, San Francisco, California 94143, USA

Corresponding email(s):  mli2@tulane.edu , pinkel@cc.ucsf.edu

Key Words:  Cytogenetics, Chromosome, FISH, Microarray, Comparative genomic hybridization (CGH)


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Li Marilyn, Pinkel Daniel. Clinical cytogenetics and molecular cytogenetics[J]. Journal of Zhejiang University Science B, 2006, 15(7): 162~163.

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Abstract: 
The short report will be focused on helping our students to understand commonly used conventional and cutting edge cytogenetic techniques and their clinical applications, the advances and drawbacks of each technique, and how to pick the right test(s) for a specific patient in order to achieve a proper diagnosis efficiently and economically.

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Reference

[1] Li, M.M., 2005. Advanced molecular and cytogenetic technologies in birth defect diagnosis and prevention. Beijing Da Xue Xue Bao, 37(1):14-19.

[2] Li, M.M., Howard-Peebles, P.N., Killos, L.D., Stanley, W.S., 2000. Molecular characterization of chromosome markers identified at prenatal diagnosis and its clinical implication. Prenat. Diagn., 20(2):138-143.

[3] Pinkel, D., Albertson, D.G., 2005. Array comparative genomic hybridization and its applications in cancer. Nat. Genet., 37(Suppl 6):S11-S17.

[4] Speicher, M.R., Carter, N.P., 2005. The new cytogenetics: blurring the boundaries with molecular biology. Nat. Rev. Genet., 6(10):782-792.

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