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Received: 2007-01-16

Revision Accepted: 2007-05-22

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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.8 P.593~598

doi: 10.1631/jzus.2007.B0593


Relationship between hyperuricemia and metabolic syndrome


Author(s):  CHEN Li-ying, ZHU Wen-hua, CHEN Zhou-wen, DAI Hong-lei, REN Jing-jing, CHEN Jian-hua, CHEN Lei-qian, FANG Li-zheng

Affiliation(s):  1.Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):  cly0906@163.com , fangli.zheng@163.com

Key Words:  Hyperuricemia, Metabolic syndrome, Triglyceride


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CHEN Li-ying, ZHU Wen-hua, CHEN Zhou-wen, DAI Hong-lei, REN Jing-jing, CHEN Jian-hua, CHEN Lei-qian, FANG Li-zheng. Relationship between hyperuricemia and metabolic syndrome[J]. Journal of Zhejiang University Science B, 2007, 8(11): 593~598.

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author="CHEN Li-ying, ZHU Wen-hua, CHEN Zhou-wen, DAI Hong-lei, REN Jing-jing, CHEN Jian-hua, CHEN Lei-qian, FANG Li-zheng",
journal="Journal of Zhejiang University Science B",
volume="8",
number="8",
pages="593~598",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0593"
}

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%A CHEN Li-ying
%A ZHU Wen-hua
%A CHEN Zhou-wen
%A DAI Hong-lei
%A REN Jing-jing
%A CHEN Jian-hua
%A CHEN Lei-qian
%A FANG Li-zheng
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%V 8
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%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer

TY - JOUR
T1 - Relationship between hyperuricemia and metabolic syndrome
A1 - CHEN Li-ying
A1 - ZHU Wen-hua
A1 - CHEN Zhou-wen
A1 - DAI Hong-lei
A1 - REN Jing-jing
A1 - CHEN Jian-hua
A1 - CHEN Lei-qian
A1 - FANG Li-zheng
J0 - Journal of Zhejiang University Science B
VL - 8
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SP - 593
EP - 598
%@ 1673-1581
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PB - Zhejiang University Press & Springer
ER -


Abstract: 
Objective: To investigate the relationship between metabolic syndrome and hyperuricemia. Methods: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. hyperuricemia is defined as ≥7 mg/dl (in men) or ≥6.0 mg/dl (in women). metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. Results: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia [odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. Conclusion: hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome.

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