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CLC number: R732.2

On-line Access: 2011-08-02

Received: 2011-06-21

Revision Accepted: 2011-07-06

Crosschecked: 2011-06-21

Cited: 10

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Citations:  Bibtex RefMan EndNOte GB/T7714

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.8 P.624-628

doi: 10.1631/jzus.B1101002


Complex pathologies of angiotensin II-induced abdominal aortic aneurysms


Author(s):  Alan Daugherty, Lisa A. Cassis, Hong Lu

Affiliation(s):  1.Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536-0509, USA, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536-0200, USA

Corresponding email(s):  Alan.Daugherty@uky.edu

Key Words:  Abdominal aortic aneurysms, Angiotensin II, Pathologies, Mouse


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Alan Daugherty, Lisa A. Cassis, Hong Lu. Complex pathologies of angiotensin II-induced abdominal aortic aneurysms[J]. Journal of Zhejiang University Science B, 2011, 2(12): 624-628.

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A1 - Lisa A. Cassis
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Abstract: 
angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Ahluwalia, N., Lin, A.Y., Tager, A.M., Pruitt, I.E., Anderson, T.J., Kristo, F., Shen, D., Cruz, A.R., Aikawa, M., Luster, A.D., et al., 2007. Inhibited aortic aneurysm formation in BLT1-deficient mice. J. Immunol., 179(1):691-697.

[2]Ayabe, N., Babaev, V.R., Tang, Y., Tanizawa, T., Fogo, A.B., Linton, M.F., Ichikawa, I., Fazio, S., Kon, V., 2006. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis, 184(2):312-321.

[3]Barisione, C., Charnigo, R., Howatt, D.A., Moorleghen, J.J., Rateri, D.L., Daugherty, A., 2006. Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography. J. Vasc. Surg., 44(2):372-376.

[4]Baxter, B.T., Terrin, M.C., Dalman, R.L., 2008. Medical management of small abdominal aortic aneurysms. Circulation, 117(14):1883-1889.

[5]Bruemmer, D., Collins, A.R., Noh, G., Wang, W., Territo, M., Arias-Magallona, S., Fishbein, M.C., Blaschke, F., Kintscher, U., Graf, K., et al., 2003. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J. Clin. Invest., 112(9):1318-1331.

[6]Choke, E., Cockerill, G., Wilson, W.R., Sayed, S., Dawson, J., Loftus, I., Thompson, M.M., 2005. A review of biological factors implicated in abdominal aortic aneurysm rupture. Eur. J. Vasc. Endovasc. Surg., 30(3):227-244.

[7]Daugherty, A., Cassis, L.A., 1999. Chronic angiotensin II infusion promotes atherogenesis in low density lipoprotein receptor −/− mice. Ann. NY Acad. Sci., 892(1):108-118.

[8]Daugherty, A., Cassis, L.A., 2004. Mouse models of abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol., 24(3):429-434.

[9]Daugherty, A., Manning, M.W., Cassis, L.A., 2000. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J. Clin. Invest., 105(11):1605-1612.

[10]Daugherty, A., Manning, M.W., Cassis, L.A., 2001. Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. Br. J. Pharmacol., 134(4):865-870.

[11]Deng, G.G., Martin-McNulty, B., Sukovich, D.A., Freay, A., Halks-Miller, M., Thinnes, T., Loskutoff, D.J., Carmeliet, P., Dole, W.P., Wang, Y.X., 2003. Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ. Res., 92(5):510-517.

[12]Hackam, D.G., Thiruchelvam, D., Redelmeier, D.A., 2006. Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet, 368(9536):659-665.

[13]Henriques, T.A., Huang, J., D′Souza, S.S., Daugherty, A., Cassis, L.A., 2004. Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice. Endocrinology, 145(8):3866-3872.

[14]Ishibashi, M., Egashira, K., Zhao, Q., Hiasa, K., Ohtani, K., Ihara, Y., Charo, I.F., Kura, S., Tsuzuki, T., Takeshita, A., et al., 2004. Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice. Arterioscler. Thromb. Vasc. Biol., 24(11):e174-e178.

[15]Jones, G.T., Thompson, A.R., van Bockxmeer, F.M., Hafez, H., Cooper, J.A., Golledge, J., Humphries, S.E., Norman, P.E., van Rij, A.M., 2008. Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arterioscler. Thromb. Vasc. Biol., 28(4):764-770.

[16]King, V.L., Trivedi, D., Gitlin, J.M., Loftin, C.D., 2006. Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler. Thromb. Vasc. Biol., 26(5):1137-1143.

[17]Lu, H., Rateri, D.L., Cassis, L.A., Daugherty, A., 2008. The role of the renin-angiotensin system in aortic aneurysmal diseases. Curr. Hypertens. Rep., 10(2):99-106.

[18]Manning, M.W., Cassis, L.A., Huang, J., Szilvassy, S.J., Daugherty, A., 2002. Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease. Vasc. Med., 7(1):45-54.

[19]Police, S.B., Thatcher, S.E., Charnigo, R., Daugherty, A., Cassis, L.A., 2009. Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler. Thromb. Vasc. Biol., 29(10):1458-1464.

[20]Powell, J.T., Brady, A.R., 2004. Detection, management, and prospects for the medical treatment of small abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol., 24(2):241-245.

[21]Rateri, D.L., Howatt, D.A., Moorleghen, J.J., Charnigo, R., Cassis, L.A., Daugherty, A., 2011. Prolonged infusion of angiotensin II in apoE −/− mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysms. Am. J. Pathol., in press.

[22]Rodin, M.B., Daviglus, M.L., Wong, G.C., Liu, K., Garside, D.B., Greenland, P., Stamler, J., 2003. Middle age cardiovascular risk factors and abdominal aortic aneurysm in older age. Hypertension, 42(1):61-65.

[23]Saraff, K., Babamusta, F., Cassis, L.A., Daugherty, A., 2003. Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol., 23(9):1621-1626.

[24]Tieu, B.C., Lee, C., Sun, H., Lejeune, W., Recinos, A.3rd, Ju, X., Spratt, H., Guo, D.C., Milewicz, D., Tilton, R.G., et al., 2009. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J. Clin. Invest., 119(12):3637-3651.

[25]Wang, J.A., Chen, W.A., Wang, Y., Zhang, S., Bi, H., Hong, B., Luo, Y., Daugherty, A., Xie, X., 2011. Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis, in press.

[26]Wang, Y.X., Cassis, L.A., Daugherty, A., 2006. Angiotensin II-Induced Abdominal Aortic Aneurysms. In: Xu, Q. (Ed.), A Handbook of Mouse Models for Cardiovascular Disease. John Wiley & Sons, p.125-136.

[27]Wang, Y., Ait-Oufella, H., Herbin, O., Bonnin, P., Ramkhelawon, B., Taleb, S., Huang, J., Offenstadt, G., Combadiere, C., Renia, L., et al., 2010. TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J. Clin. Invest., 120(2):422-432.

[28]Yoshimura, K., Aoki, H., Ikeda, Y., Fujii, K., Akiyama, N., Furutani, A., Hoshii, Y., Tanaka, N., Ricci, R., Ishihara, T., et al., 2005. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat. Med., 11(12):1330-1338.

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