The Unconventional LRRC8 VRAC-STING Signaling and Metabolic-epigenetic Regulation of Antiviral and Antitumor Immunity

Date: 2021-06-23 10:01:31
Time: 15:30-16:30
Venue: International Campus
Speaker: XIAO Hui
Category: Talk & Lecture

Venue: Room A203, ZJE Building, International Campus, Haining

Speaker: Prof. XIAO HuiUnit of Immune Signaling and Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences


The major goal of Prof. Xiao research is to decipher the signaling mechanisms by which pattern-recognition receptors such as TLRs, CLRs, RLR and cGAS/STING induce the expression of cytokines (including IL-12, IL-10, and IL-23) and IFN-a/b, reprogram cell metabolism and epigenetics, and coordinate cell death/survival. The ultimate goal is to understand how the innate immune system manages to coordinate the adequate innate and adaptive immune responses to combat pathogens and cancer while tolerating commensals. His lab has recently published several high-impact works in Nature Immunology, Immunity, JEM and JCI, etc.