Recently, the research teams led by ZHANG Yan from the Zhejiang University School of Medicine and Zhejiang Laboratory for Systems & Precision Medicine, SUN Jinpeng from Peking University and Shandong University, and H. Eric Xu from the CAS Shanghai Institute of Materia Medica co-published an article entitled “Structures of glucocorticoid-bound adhesion receptor GPR97-Go complex” in Nature. It is the first time that the structure of adhesion GPCR–G complexes has been identifi...

As COVID-19 has been raging across the globe in the past year, it has not only constituted tremendous hazards to the safety and well-being of human beings but also incurred immeasurable economic losses. Although most of COVID-19 patients remain asymptomatic or experience only mild symptoms, about 20% suffer overt pneumonia and roughly 5% cases progress to life-threatening Acute Respiratory Distress Syndrome (ARDS) and severe or atypical systemic inflammation. Then how does COVID-19 differ from c...

Hepatocellular carcinoma (HCC) is the most common primary liver tumor with an increasing global incidence. In 2018, HCC was the sixth most frequently diagnosed cancer and the fourth leading cause of cancer-related death worldwide. Sorafenib is the first FDA-approved targeted therapy for advanced HCC. A previous study showed that sorafenib prolonged the median overall survival (OS) by 2.3−3 months in advanced HCC patients that did not qualify for liver transplantation or resection. However, soraf...

Hearing impairment may result from a multitude of factors, including heredity, environment and their interactions. Mitochondria are the hub of energy metabolism in eukaryotic cells and the control center of cellular signaling. tRNA plays a crucial role as a carrier of amino acid transport during protein synthesis. A lot of posttranscriptional modifications exist in mitochondrial tRNAs (8.7%). In human mitochondria, 18 types of nucleotide modifications are present in the 137 positions of 22 tRNA ...

Extracellular vesicles (EVs) are superb potential vectors for the delivery of therapeutic drugs with their low immunogenicity and cytotoxicity. However, issues with biological safety and disease targeting substantially limit their clinical application. EVs from red blood cells (RBC-EVs) are a potential drug delivery vehicle, given their high production and beneficial characteristics in biosafety. The research team led by Prof. CAI Zhijian from Zhejiang University School of Basic Medical Sci...

Alzheimer’s disease (AD) is a severe neurodegenerative disorder that exerts an extremely adverse impact on individuals, families and society at large, with symptoms such as memory loss, cognitive dysfunction mood swings and loss of kinetic abilities. At present, there are about 50 million people worldwide with AD and this number is projected to soar to 152 million. AD is one of the most financially costly diseases. Currently, 1 trillion dollars or so is spent annually worldwide on the trea...

The novel coronavirus pandemic is still spreading across the world. As reported by WHO, there have been more than 6.4 million confirmed cases and more than 380 thousand deaths globally. With rapidly increasing number of confirmed cases in South American countries like Brazil, it warns us that this pandemic is far from over.Since the outbreak of the pandemic, The Fourth Affiliated Hospital, Zhejiang University School of Medicine (ZJU4H) has been actively participating the nationwide concerted eff...

Drawing upon the firstline experience of the Second Affiliated Hospital of Zhejiang University School of Medicine in the fight against the pandemic, a guidebook – COVID-19 outbreak: Hospital Response Strategy was released on April 11, which offers applicable references to a wider audience.The English and Chinese version of this book can be downloaded through GMCC ( Global MediXchange for Combating COVID-19, covid-19.alibabacloud.com). GMCC programme is established by Jack Ma Foundation...

Handbook of COVID-19 Prevention and Treatment, sponsored by Jack Ma Foundation and Alibaba Foundation and compiled by a panel of medical experts from the First Affiliated Hospital, Zhejiang University School of Medicine (FAZHU) according to their clinical experience in fighting the pandemic, was officially released on March 18.  This handbook is based on the guidelines on prevention, control, diagnosis and treatment by the National Health Commission of China. It summarizes the first-ha...

On January 16, the “brain-computer interface” research team from the Zhejiang University Qiushi Academy for Advanced Studies announced that together with the Second Affiliated Hospital of Zhejiang University, it had completed China’s first clinical translational study of the motor function reconstruction at the brain-computer interface. The 72-year-old paraplegic patient could take full advantage of the cerebral cortex EEG signals to precisely control an external robotic arm and a manipulator...