ZJU scientists develop “musical dish” to induce osteogenic differentiation through music derived microstretch with variable frequency
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2022-03-06
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Stretch, as a form of mechanical force, plays a crucial role in regulating cell behaviors, preventing injuries and repairing tissues such as lung, heart, brain and skeletal system. Among them, stretch in bone tissues has captured the most immense attention in clinical applications, for bone tissues are continuously exposed to stretch stimulation during physiological activities. The structure and function of bone tissues relies on a proper amount of stretch stimulation, while lack of exercises te...
New mechanism in preventing CAR-T cell exhaustion
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2022-03-04
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In recent years, chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable success in treating patients with relapsed or refractory leukemia and lymphoma. Even so, a significant proportion of patients relapse after treatment with CAR-T cells. The dysfunction of CAR-T cells, such as exhaustion, is one of the critical causes of relapse. Reducing CAR-T cell exhaustion is the key to improving efficacy and remains a global problem that urgently needs to be solved.On January 14, 2022, P...
ZJU scientists discover novel approach to robustly producing functional human pancreatic β cells for curing diabetes
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2022-03-03
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Diabetes, a global chronic disease, affects millions of people worldwide. Islet transplantation holds immense promise as a cure for diabetes, but it is circumscribed by shortage of organ donors and immunosuppression issues. Differentiation of Human pluripotent stem cells (hPSCs) is regarded as an effective solution to cell-based therapy.On February 23, Prof. ZHU Saiyong’s lab at the Zhejiang University Life Sciences Institute published an article entitled “Human expandable pancreatic prog...
Unravelling the mystery of East Asia’s largest dust storm in a decade
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2022-03-02
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Last spring, China and some other Asian countries were plagued several times by dust storms, among which the dust storm that occurred in mid-March was considered to be the worst in the past decade in China. Large-scale dust storms, which have been dormant for years, have undergone a dramatic resurgence, seriously jeopardizing people’s life. What were the initial sources of the dust? How were its transport pathways? What kind of mechanism did trigger the event? All these pertinent scientific que...
Marine pastures equipped with “giant pumps” to reduce carbon and purify water
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2022-03-01
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By the end of December 2021, China’s first artificial upwelling demonstration project, located in the waters of Aoshan Bay in Qingdao, had been in operation for 40 months. In this project, an artificial system is installed to form seawater upwelling which can transport nutrient-rich seawater to the euphotic layer on the surface. In this way, the growth of phytoplankton and algae can be promoted, thereby improving primary productivity, restoring the marine ecological environment, and enhanc...
ZJU’s “Heritage Ark” is setting sail on the journey of bringing cultural relics to life
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2022-02-28
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At the 7th China International College Students’ “Internet+” Innovation and Entrepreneurship Competition, a Buddha statue from the northern wall of the Guyang Cave in the Longmen Grottoes was “moved” to the exhibition site. A team named “Heritage Ark” from Zhejiang University replicated relics with 3D printing technology and brought them back to life. Since then, those precious Buddha statues perching in caves have been open to the general public.Heritage Ark...
ZJU scientists elucidate novel molecular mechanism of MYBPC3-related hypertrophic cardiomyopathy using human iPSC-CM model
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2022-02-25
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Hypertrophic cardiomyopathy (HCM), characterized by left ventricular hypertrophy and fibrosis, is the most common monogenic cardiovascular disorder with global distribution and diverse clinical spectrum. The disease prevalence has been estimated at approximately 1:500 in the general population and even higher (1 case per 200) when both clinical and genetic diagnoses are taken into accounts. Patients with HCM are predisposed to heart failure, outflow tract obstruction and arrhythmias. The most vi...
Licensing but not fueling: a metabolic enzyme promotes mitosis beyond metabolism
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2022-02-23
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Uncontrolled cell proliferation is a hallmark of cancer. To sustain the ceaseless cell division, cancer cells rewire metabolic pathways in order to provide sufficient nutrient and energy for mitotic progression. Metabolic reprogramming of cancer cells is usually orchestrated by dysregulation of metabolic enzymes. It is generally thought that dysregulated metabolic enzymes contribute to cell cycle progression mainly by providing essential metabolites to meet the cellular needs for biosynthesis an...
Therapeutic potential of opioid agonists in human leukemia
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2022-02-22
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Leukemia, the blood cancer, is a group of hematopoietic malignancies. Many types of leukemia are associated with poor outcome. Unfortunately, during the past a few decades, the first-line leukemia therapy has long been traditional chemotherapy with high cytotoxicity and low selectivity, such as the “7+3” strategy, i.e., a combination of cytarabine and doxorubicin. Also, side effects of such intensive chemotherapies are often severe, especially in elder patients. Therefore, it is in urgent need...
Unraveling correlation of Cd induced metabolic toxicity and diabetes
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2022-02-17
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Diabetes has become the leading metabolic disease threatening human health. Meanwhile, the association between exposure to harmful environmental factors and the occurrence of diabetes has always been a hot spot of public health and environmental medicine.A recent study conducted by Dr. ZHOU Zhou’s lab at the Department of Environmental Medicine, the Zhejiang University School of Medicine elucidated the Cd perturbed metabolomic signature in pancreatic beta cells and human urine. The origina...