Autologous CAR T-cell therapy, in which a patient’s own T-cells are re-engineered to recognize and bind to specific antigens on the surface of cancer cells, represents a groundbreaking advancement in immunotherapy and is now a standard of care for certain hematologic malignancies. However, this bespoke form of treatment has yet to gain a toehold in solid tumors, owing to challenges such as limited cell proliferation, insufficient tumor infiltration, and a tumor microenvironment that fosters imm...

Some gut bacteria can collaborate to promote T-cell action against tumours in mice, raising hopes for treatments.A new study led by Zhejiang University researchers has identified ways by which some microbes might influence cancer immunotherapy, suggesting a potential microbial-based adjuvant approach to improve the responsiveness of immunotherapy. Their results were published in Cell1 in March 2024.Doctors and scientists have long been puzzled about why some patients respond better tha...

"It's wonderful that my daughter doesn’t need dialysis anymore. Her skin is lightened and she becomes more outgoing. Thank you so much for giving my child a chance at living a quality life with a kidney transplant."Standing in the ward of the Urology Department at the Children’s Hospital of Zhejiang University School of Medicine (ZCH), Miao Miao's mother expressed her gratitude while preparing for her discharge from the hospital.Miao Miao is a 13-year-old ...

Bone is one of the most common sites of early metastasis of cancer and is also a "hotbed" for tumor cells. Why do tumor cells go after hard bones first? The latest study by teams from Prof. FAN Shunwu and Prof. LIN Xianfeng’s Lab from Sir Run Run Shaw Hospital (SRRSH), affiliated with Zhejiang University School of Medicine, found that they are directed at osteoclasts, the only cells in the human body that can secrete acid and dissolve bone. By feeding them closely, tumor cells "r...

In a significant stride for China's presence on the global stage of cell immunotherapy, Professor HUANG He from theBone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZU) has been at the forefront, showcasing remarkable advancements in CAR T-cell therapy. Recently, the contributions of his team were highlighted in February, during the 6th European CAR-T Conference held in Valencia, Spain, where he delivered insig...

Chimeric Antigen Receptor T-cell (CAR-T) therapy, a pioneering treatment for B-cell malignancies, has garnered significant attention lately due to its promising potential in tackling severe autoimmune disorders, especially systemic lupus erythematosus (SLE). Nonetheless, there is a notable absence of reported applications of CAR-T therapy in pediatric SLE patients.In March 2024, the Children's Hospital of Zhejiang University School of Medicine initiated the groundbreaking use of CAR-T t...

On March 5, the research team led by Professors YU Yanqin, DUAN Shumin and YANG Hongbin from the Zhejiang University School of Brain Science and Brain Medicine published an open-access article titled “Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons” in the journal National Science Review. This groundbreaking work reveals, for the first time, the crucial role of GABAergic neurons in the nucleus of Darkschewitsch (ND) in modulating defensive behavior, t...

Freeze-drying technique, commonly used for preparation of snacks from fruits and vegetables, is now utilized for generating therapeutic materials for cancer treatment. The freeze-drying process could maintain the color, flavor, and nutritional content of food by removing water from solid to gas phase directly under reduced pressure and low temperature. It is being harnessed to preserve active components and structures of human tissues as drug depots.Freeze-dried fruits and vegetables.Led by Prof...

In March, SAHZU transplantation team traveled 4000 km and demonstrated SAHZU surgical techniques in the Central Asian country of Uzbekistan.From March 11 to 15, Prof. WANG Weilin, President of the Second Affiliated Hospital Zhejiang University School of Medicine (SAHZU), and a SAHZU multidisciplinary team paid a visit to Uzbekistan for a five-day surgical operation demonstrations and academic exchange activities at the Republic Specialized Scientific-Practical Medical Center of Surgery Named Aft...

XU HaoxinDean, School of Basic Medical Sciences,Zhejiang UniversityQiushi Chair Professor of Zhejiang UniversityProfessor of Liangzhu LabVisiting Professor,Department of Biology,University of MichiganPresidential Early Career Award for Scientists and Engineers 2010Researcher of the New Cornerstone Investigator Program 2023President of the Zhejiang Society for Neuroscience Q1: What made you decide to come to Zhejiang University?XU: There are two things I considerfrequently:how to create some...