Recently, the research teams led by ZHANG Yan from the Zhejiang University School of Medicine and Zhejiang Laboratory for Systems & Precision Medicine, SUN Jinpeng from Peking University and Shandong University, and H. Eric Xu from the CAS Shanghai Institute of Materia Medica co-published an article entitled “Structures of glucocorticoid-bound adhesion receptor GPR97-Go complex” in Nature. It is the first time that the structure of adhesion GPCR–G complexes has been identifi...

As COVID-19 has been raging across the globe in the past year, it has not only constituted tremendous hazards to the safety and well-being of human beings but also incurred immeasurable economic losses. Although most of COVID-19 patients remain asymptomatic or experience only mild symptoms, about 20% suffer overt pneumonia and roughly 5% cases progress to life-threatening Acute Respiratory Distress Syndrome (ARDS) and severe or atypical systemic inflammation. Then how does COVID-19 differ from c...

Imagine that in the future, a “mobile hospital” bus complete with necessary medical equipment will make it to your neighborhood on time as long as you click the “reservation” on your mobile phone.On January 23, the 5G “Mobile Digital Hospital” built by the Fourth Affiliated Hospital of the Zhejiang University School of Medicine (ZJU4H) was officially launched. It is the first “mobile hospital” to provide medical services in the whole process in Zhejiang Province. Based on a mobile CT car...

The research team led by Prof. CHEN Xuexin from Zhejiang University College of Agriculture and Biotechnology and the research team led by Prof. ZHAN Shuai from Chinese Academy of Sciences co-published a research article entitled “Two novel venom proteins underlie divergent parasitic strategies between a generalist and a specialist parasite” in Nature Communications, revealing the novel mechanism for diverse parasitic strategies among parasitoid species. Parasitoid wasps have been extensively u...

Hepatocellular carcinoma (HCC) is the most common primary liver tumor with an increasing global incidence. In 2018, HCC was the sixth most frequently diagnosed cancer and the fourth leading cause of cancer-related death worldwide. Sorafenib is the first FDA-approved targeted therapy for advanced HCC. A previous study showed that sorafenib prolonged the median overall survival (OS) by 2.3−3 months in advanced HCC patients that did not qualify for liver transplantation or resection. However, soraf...

On January 15th, the Royal Society of Chemistry (RSC) awarded the Felix Franks Biotechnology Medal to GU Zhen, Qiushi Chair Professor of Zhejiang University and Dean of College of Pharmaceutical Sciences, for his fundamental and technological innovations in the drug delivery field for the treatment of diabetes and cancers. The award ceremony was held at Zhejiang University. Authorized by the RSC Felix Franks Biotechnology Medal Committee, Prof. ZHOU Tianhua, Zhejiang University Vice President, g...

While in class, her pace is agile and brisk, her eyes are glittering and lively, and her teaching is remarkably logical and meticulous with a string of typical cases. WANG Jiewei, a faculty member at the School of Medicine and a doctor at the First Affiliated Hospital of the Zhejiang University School of Medicine, clinched the grand prize in the finale of Zhejiang University Young Teachers’ Teaching Competition 2020. She still has a vivid memory of her teachers, JI Feng and CHEN ...

Hearing impairment may result from a multitude of factors, including heredity, environment and their interactions. Mitochondria are the hub of energy metabolism in eukaryotic cells and the control center of cellular signaling. tRNA plays a crucial role as a carrier of amino acid transport during protein synthesis. A lot of posttranscriptional modifications exist in mitochondrial tRNAs (8.7%). In human mitochondria, 18 types of nucleotide modifications are present in the 137 positions of 22 tRNA ...

The eighth day of the last lunar month marks the Laba Festival (Chinese: 腊八节). Laba festival is regarded as the prelude to the Chinese Spring Festival. A catchy nursery rhyme about the festival goes like this: “Kids, kids, don't be greedy. When Laba is here, the Spring Festival isn't far away.” After Laba, families will start their preparation for the Spring Festival: cleaning the house, setting up decorations, shopping and filling their fridges, etc.On...

Sex chromosomes genetically determine the remarkable differences between sexes from reproductive organs to the appearances and behaviors of adult individuals, and exhibit many genomic features and evolutionary patterns that are distinct from autosomes. They have long been the central subject of research for biologists.Classical theories of sex chromosome evolution suggest that sex chromosomes often originate from a pair of ancient autosomes and that homologous recombination between sex-determini...