A novel “biological missile” targeting malignant tumor
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2021-10-04
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The team led by Prof. CHEN Shuqing and Prof. PAN Liqiang at the Zhejiang University College of Pharmaceutical Sciences published their latest research findings regarding a multivalent biparatopic EGFR-targeting nanobody drug conjugate in the journal Signal Transduction and Targeted Therapy on September 3. Design of multivalent anti-EGFR nanobody drug conjugateAn antibody-drug conjugate (ADC) is a type of anticancer drug linking an antibody with cytotoxic molecules. It integra...
HU Hailan wins L'Oréal-UNESCO Award for Women in Science
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2021-10-03
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HU Hailan, professor at Zhejiang University School of Brain Science and Brain Medicine and director of the MOE Frontier Center of Brain Science and Brain-machine Integration, has been honored with the 2022 L’Oréal-UNESCO for Women in Science International Award in recognition of “her major discoveries in neuroscience, in particular her work on depression, which has informed the development of next generation drugs for depression”.Founded in 1998, the Award annually celebrates the scient...
Novel therapeutics against obesity by activating melanocortin-4 receptor
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2021-10-02
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Satiety in the gut is regulated by the nervous system. The melanocortin-4 receptor (MC4R) in the hypothalamus is known as the brain’s “switchboard” to control appetite and metabolism. It is a popular target for the treatment of such metabolic diseases as obesity by regulating the body’s energy metabolism and eating behavior in response to the simulation of proopiomelanocortin (POMC) and agouti-related peptide (AgRP) by various metabolic signals such as leptin and neuropeptide Y. MC4R belongs...
Dialogue@ZJU: With the winning team of the Most Promising Design award in the BRIDGE Sustainable Design Action
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2021-09-29
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[Editor’s note: The BRIDGE Design Week 2021 wrapped up in Zhejiang University on Sept 11, with 10 teams of students from 17 universities around the world presenting their design proposals to help achieve the United Nations’ sustainable development goals (SDGs). Team Six “200%” won the Most Promising Design award with their proposal “GO ON”. What’s special about their design? ZHANG Hongbo, the team leader, shared his understanding of SDGs and the concept behind their design.]Q1: ...
Sino-German forum highlights multi-stakeholder approach to 2030 Agenda
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2021-09-27
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The inaugural Sino-German Sustainable Development Forum took place in hybrid format on September 24. The event brought together over 30 experts from both countries under major themes including climate change and environment, new energy materials, green development policies and university-industry cooperation.ZJU’s Vice President HE Lianzhen joined officials and organization leaders at the opening session. She started with an overview of ZJU’s historical and vibrant, ongoing ties with Germany, ...
New mechanism of parasitoid wasps in avoiding intraspecific competition
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2021-09-27
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Parasitic wasps are natural enemies for effective control over the population of pests in nature. Hence, they are extensively used as green agents of pest control in agriculture and forestry. There are a diversity of parasitic wasps, which have assorted parasitic habits. In general, parasitism can be divided into three types: solitary parasitism, gregarious parasitism and synparasitism. Superparasitism—two or more eggs being laid into a single host by one or more parasitoid females—usually leads...
ZJU scientists reveal the mechanical activation of SARS-CoV-2 spike to foster viral invasion
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2021-09-24
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SARS-CoV-2 utilizes its spike protein to recognize host angiotensin-converting enzyme II (ACE2) receptor, which induces subsequent S1/S2 detachment of spike for forming fusion machinery to invade host cells. However, only small structural changes of spike occur upon ACE2 binding, which raises questions whether these small conformational changes are enough to trigger the detachment of tightly associated S1/S2 subunits. If not, what additional factors are required?The research team led by Dr. CHEN...
ZJU scientists develop a novel tool for single-cell transcriptomics
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2021-09-23
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On September 9, Nucleic Acids Research reported the latest findings of the research team led by Prof. FAN Xiaohui at the Zhejiang University College of Pharmaceutical Sciences and Prof. CHEN Huajun at the Zhejiang University College of Computer Science and Technology—scDeepSort: a pre-trained cell-type annotation method for single-cell transcriptomics using deep learning with a weighted graph neural network. With cells and genes treated as the nodes of the graph neural network and...
ZJU wishes you a Happy Mid-Autumn Festival
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2021-09-21
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Today is Mid-Autumn Festival, an important occasion for family reunion in China and a time to enjoy the colorful Qiushi mooncakes with our alumni. Apart from eating mooncakes and appreciating the moon, there are many other celebrations taking place around the campus. Tea parties are being held with the mooncake DIY, tea tasting and traditional painting and calligraphy. To all the ZJUers across the globe, may this festival of harvest bring eternal joy and happiness in your lives. &nbs...
ZJU freshman WU Qingfeng claims women’s 4×100m freestyle relay gold at the National Games
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2021-09-20
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On Sept. 19, ZJU freshman WU Qingfeng, along with her teammates, snatched women’s 4×100m freestyle relay gold at the National Games. Just two months ago, the same quartet ranked 7th in the relay at the Tokyo Olympics, setting an Asian record of 3 minutes 34.76 seconds.Shortly before the National Games, Wu came to Zijingang Campus for the registration. Impressed by the big and beautiful campus, she hoped that she would learn to balance training and college study. “I look forward to a...