The immune checkpoint inhibitors, including anti-PD-1 and anti-PD-L1 antibodies (αPD-1 and αPD-L1), have revolutionized tumor immunotherapy. Although αPD-1 and αPD-L1 show excellent efficacy in various tumor types, even in patients with advanced tumors, only 10-30% of patients respond to αPD-1 and αPD-L1 therapy due to primary resistance. Extracellular vesicles (EVs) are highly involved in the progression of the tumor. PD-L1+ tumor-derived EVs (TEVs) cause systemic immu...

[Editor’s Note: Our world is facing many global challenges, from poverty to hunger, from climate change to energy crisis, from inequality to digital gap. How can we tackle these urgent problems? What role should young generation play? In this three-episode dialogue, ZJU students voice their own thoughts on Sustainable Development Goals. LIN Weiwei (English, ’23) called on young people to rebuild faith and rewrite the stories of denial to the ones of motivation at the China-Europe-America Youth...

The research team led by Prof. GUO Guoji and Prof. HAN Xiaoping at the Zhejiang University School of Medicine published an article entitled “Deep learning of cross-species single cell landscapes identifies conserved regulatory programs underlying cell types” in the journal Nature Genetics on October 13.In their study, the researchers employed their independently-developed Microwell-seq to construct organism-wide cell landscapes for zebrafish, Drosophila and earthworms using...

The human uterine organ, especially the full-thickness endometria, is essential for fertilization and embryonic development. Human endometria, which mainly comprise endometrial epithelial and stromal cells, exhibit remarkable plasticity and undergo repeated injury and regeneration. The highly dynamic properties of repeated injury and scar-less repair during the menstrual cycle make it an ideal model to study tissue regeneration. Full-thickness injury or dysfunction of the human endomet...

[Editor’s Note: On October 27th 2021, Prof. Der-Horng Lee joined the International Campus, Zhejiang University, and was formally inaugurated as the Dean of ZJU-UIUC Institute. On the same day, invited as the honorable guest for the 7th High Table Dinner, Prof. Lee delivered his first public speech on the campus, sharing his insights into talent training and research.] One’s important qualitiesAside from our study and research, to begin with my sharing tonight, I think it is important...

On October 14, Prof. WU Zhaohui, president of Zhejiang University had a virtual meeting with Prof. Paul Alivisatos, president of the University of Chicago. Also present at the meeting were Katie Hrinyak, assistant vice president for Global Initiatives and Strategy at the University of Chicago, and LI Min, director of the Office of Global Engagement at Zhejiang University. WU Zhaohui extended his heartfelt congratulations to Paul Alivisatos on Douglas Diamond’s winning of the 2022 Nobel Prize fo...

Ovarian cancer is one of the most common malignancies of the female reproductive system and the leading cause of gynecological cancer-associated death. Although surgery and adjuvant chemotherapy are possible therapeutic options, the 5-year survival rate of advanced ovarian cancer remains less than 30%. Poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors for clinical use have greatly improved the survival rates for ovarian cancer patients with homologous recombination repair (HRR) de...

At Zhejiang University, there is such a team who has cycled in all prefecture-level cities in Zhejiang Province, and whose total mileage has added up to 150,000 kilometers, literally equivalent to 4 times around the equator.The team called Team ZJU Road Bike Club was established in 2015 by road cycling enthusiasts at Zhejiang University. It now has more 600 members, including both novice and professional cyclists. It ranks among Top 10 in the amateur category of Zhejiang Provincial Cycling Leagu...

Flying disc, a trending sport, goes viral on campuses for its fun competition, less physical contact and social interactions. As Ultimate—the disc competition governed by Spirit of the Game—is increasingly finding favor among the young, Zhejiang University’s Ultimate team, Hawk Soar, is also soaring in popularity. Today let’s turn the spotlight on their stories with discs.Why “Hawk Soar”?Hawk Soar is a team of Ultimate-fans led by LIU Chenlu, a graduate student in ZJU’s Life Science Institu...

Primary ovarian insufficiency (POI) is a clinical syndrome defined as premature exhaustion of the resting pool of primordial follicles before the age of 40 years and characterized by oligo-/amenorrhea for at least 4 months with elevated gonadotrophins. Approximately 1% of women under 40 years of age are affected. POI causes severe daily life disturbances in these patients, including hot flashes, sweating, sleep disorders, vaginal dryness, depression, and compromised mental health. Another major ...