After being diagnosed with diffuse large B-cell lymphoma more than 4 years ago, Mr. Sun has gone through a long and painful treatment including 14 times of chemotherapy with different regimens, 20 times of radiotherapy and total gastrectomy. The efficacy however was far from satisfying with the tumor recurred repeatedly."Fate has already sentenced me to death, and I failed to see any hope."In May 2020, Mr. Sun turned to the First Affiliated Hospital, Zhejiang University School of Medic...

Alzheimer's Disease (AD) is characterized by a decline in cognitive function, memory loss, and in severe cases, language impairment, and ultimately the loss of independent living ability. According to estimates by Chinese Center for Disease Control and Prevention, there are about 10 million AD patients in China, which will exceed 30 million by 2050, making it the country with the largest number of AD patients in the world. However, at present, Chinese residents have low awareness a...

As an important carrier of material and energy metabolism, the ordinated modulation of organelle-associated molecules are vital for proper cellular and systemic functions. For example, sterol-regulatory element binding proteins (SREBPs), located on the surface of the endoplasmic reticulum (ER), can rapidly sense changes in intracellular lipid levels, modulate the rate of lipid synthesis to maintain cellular metabolic homeostasis. Ras-related GTP-binding proteins (RAGs) can recruit mTORC1 to the ...

In the board of officers meeting of Asia-Pacific Association of Cataract & Refractive Surgeons (APACRS) on August 27, Prof. YAO Ke, chair of SAHZU Eye Center, officially took over the presidency of APACRS in succession to Prof. Abhay Vasavada. This is the first time that a Chinese ophthalmologist has chaired the Asia-Pacific Society in this field.On behalf of the past board of officers, Prof. Abhay Vasavada warmly congratulated Prof. YAO Ke on his new position. Prof. Vasavada said that ...

Thanks to high-throughput single-cell RNA sequencing (scRNA-seq), it is possible to construct single-cell transcriptomic atlases at the organic level. For example, cell atlases for vertebrate and invertebrate systems have been successfully generated, such as Human Cell Landscape (HSC), Mouse Cell Atlas (MCA), Zebrafish Cell Landscape (ZCL) and Drosophila embryo. However, most of these studies are limited to one specific species or period and thus fail to make a thorough comparison between d...

On July 26, the research team headed by Prof. GUO Guoji from the Zhejiang University School of Medicine published an open-access article entitled “Cell landscape of larval and adult Xenopus laevis at single-cell resolution” in the journal Nature Communications. They constructed the Xenopus cell landscape (XCL) using Microwell-seq, a self-developed high-throughput single-cell RNA sequencing platform. This comprehensive XCL contained over 500,000 single cells isolated from four Xenopus...

The classical protein secretion pathway considers that the secreted protein can be recognized by the signal recognition granule after the free ribosome synthesizes the signal peptide, and the ribosome is carried to the endoplasmic reticulum by the signal recognition granule to continue the protein synthesis. At the same time, under the guidance of the signal peptide, the newly synthesized protein enters the endoplasmic reticulum cavity, and is successively transported to the Golgi apparatus and ...

The research team led by Prof. XIAO Feng-Shou and Dr. WANG Liang from the Zhejiang University College of Chemical and Biological Engineering in collaboration with Prof. ZHENG Anmin’s team from Chinese Academy of Sciences developed a novel catalytic system that can lead to a remarkable increase in the efficiency of coal-to-olefins. This study has important implications for the development of low-temperature efficient catalysts and the clean production of chemicals from coal. The findin...

[Editor’s Note: As perovskite solar cells are connected together to form a solar module, cells that are shaded in the module, such as by a fallen leaf, can be driven into reverse-bias operation by cells with higher current output. A recent study featured on the cover of the journal Joule shows how perovskite solar cells can face additional challenges beyond those of silicon cells and proposes innovative strategies for addressing them.] Perovskite solar cells are widely regarded as a promis...

The rapid outbreak of coronavirus disease 2019 (COVID-19) threatens global health, and some of infected patients are in critical condition. Microorganisms residing in the gut and respiratory tract can alter susceptibility to and the outcomes of infectious diseases. However, the role of respiratory tract microbes and the relationship between respiratory tract and gut microbiomes in COVID-19 remain uncertain.On July 6, 2022, Prof. SHEN Yifei from the First Affiliated Hospital, Zhejiang University ...