For patients suffering from sudden illnesses such as myocardial infarction and severe hypoglycemia, prompt administration of emergency medications is imperative, otherwise they may be at great risk of death. Actually, a large number of deaths still occur due to untimely emergency care caused by the lack of emergency equipment and therapeutics around the patients, or the inability of the patient to call for help, or traffic congestion.To this end, the team of Prof. GU Zhen and Prof. YU Jiche...

The Deep-time Digital Earth (DDE) Platform (Deep-time.org 1.0 Alpha), led by Prof. DU Zhenhong at the Zhejiang University School of Earth Sciences, was officially launched on November 8, 2022. Prof. Jennifer McKinley, president of the DDE’s Governing Council, announced this exciting news in the presence of nearly 50 participants attending the meetings of the Governing Council (GC) and the Scientific Committee (SC) of the DDE at UNESCO Headquarters in Paris.Prof. Jennifer McKinley anno...

Substance metabolism and energy metabolism are two basic characteristics of life activities. Autophagy is also regulated by substance and energy metabolismand in turn participates in regulating them. So far, the molecular mechanism of substance metabolism regulating autophagy is relatively clear. Autophagy can be induced by amino acid starvation, nitrogen source starvation, growth factor deprivation, or rapamycin treatment, and a series of signal molecules and degradation substrates have be...

[Editor’s note: Set up in 1986, Chu Kochen Scholarship is the highest honor for ZJU students. TANG Mengxia, among 12 undergraduate students and 12 graduate students, is a recipient of Chu Kochen Scholarship for academic year 2021-2022. An undergraduate as she is, Tang has become a rather experienced researcher, who holds the ambition to trace back by thousands of years to discover the origin of China. In this dialogue, we will learn more about the field she deems so fascinating, as well as the ...

Spinach has left deep childhood memories for many post-70s and post-80s generations because of the cartoon image of Popeye. Apart from appearing on our table as usual, it is truly endowed with the expectation of great power by scientists. The team of Dr. LIN Xianfeng and Prof. FAN Shunwu, from the orthopedics of Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, and the team of Prof. TANG Ruikang from the Zhejiang University Department of Chemistry, successfully...

Acid-base dissociation constant (pKa), a key physicochemical parameter describing the ionization ability of molecules, plays a vital role in chemical, environmental, agricultural, and medical sciences. In drug discovery, pKa determines the ionization states of drug-like molecules in the physiological environment, thus affecting a wide range of biopharmaceutical properties.Graph Neural Networks (GNN) are a set of deep learning (DL) algorithms that can learn representation automatically from ...

2022 was undoubtedly a year of many challenges and changes, but it was also a year of great achievement.We released ZJU’s refreshed global strategy in June, seeking to maximize the university’s impact on the world stage, joined hands with our global partners to launch the inaugural SDG Global Summer School in August, which attracted nearly 1,000 outstanding students from more than 80 countries and regions, and hosted the TWAS 16th General Conference in November, where the released Hangzhou Dec...

The COVID-19 outbreak in 2019 has had a huge impact on global public health. The outbreak meanwhile has also promoted the development and application of vaccine platforms, especially those based on mRNA lipid nanoparticles. However, the mode and difference in role of different mRNA nanocarriers in the induction of antiviral humoral immunity and cellular immunity is still not systematically understood.Virus-specific humoral immunity and cellular immunity are the primary objectives of antiviral va...

Scientists at Zhejiang University, including Prof. XI Wang and Prof. Anna Wang Roe at the Interdisciplinary Institute of Neuroscience and Technology and Prof. QIAN Jun at the College of Optical Science and Engineering, utilize a bright aggregation-induced emission (AIE) probe to achieve a large-depth three-photon fluorescence imaging of cortical microvasculature on nonhuman primates in vivo. Their research findings were published in the journal Biomaterials.In humans and nonhuman ...

On December 20, the research team led by Prof. GAO Zhihua and Prof. DUAN Shumin at the Zhejiang University School of Brain Science and Brian Medicine published an open-access research article titled “Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity”.Microglia, the primary immune cells and key guardians of brain activity in the brain, can constantly monitor the microenvironment to maintain brain homeostasis. When subje...