Zhejiang University: Bigger starts here
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2021-03-03
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For over a century, Zhejiang University has been inspiring different individuals to reach their potential. This is a place where you get pushed to your limits and fulfill your life’s goal. And there is something far beyond your personal fulfillment. At ZJU, addressing challenges is the everyday mission. This is the home where you get inspired to make a difference in the world.As we honor the rich tradition of the University's 124 years of journey, we’ll continue our commitment to working f...
Raman imaging technique in intraoperative assessment and photothermal ablation of tumor margins
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2021-03-01
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Surface-enhanced Raman scattering (SERS) imaging technique is marked by its superb sensitivity, minimal background interference, and minimal damage to normal tissues for biomedical application. Moreover, the Raman probe has the advantages of high specificity and ultra-low signal interference, thus showing immense promise in the biomedical field. Due to its special application context, most of current researches are primarily focused on in vitro cancer diagnosis, which is confined to the diagnosi...
Scientists discover the story behind the substrate-specific recognition of IKKs
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2021-02-26
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The nuclear factor κB (NF-κB), a protein complex that regulates gene transcription, is widely present in eukaryotic cells. It can specifically bind to promoters or enhancers to promote the transcription and expression of multiple genes. The NF-κB signaling pathway is closely bound up with the immune response and critical pathophysiological processes such as cell proliferation, transformation, and apoptosis. The classic NF-κB pathway is dominated by the role of IKKβ, which phosphorylates Iκ...
ZJU scientists develop macromolecular drug for cancer therapy via extracellular calcification
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2021-02-25
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Cancer is one of the leading causes of mortality. Chemotherapy is still the most commonly used treatment for cancer patients. It typically relies on drug endocytosis and inhibits tumor cell proliferation via intracellular pathways. However, most chemotherapy drugs damage normal cells since they work by affecting the physiological processes of cell proliferation. The side effects of systemic chemotherapy used to treat cancer are often severe and may damage the tumor‐bearing host, especially the i...
ZJU scientists discover new mechanism of HBV-ACLF
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2021-02-24
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Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver diseases, regardless of the presence of cirrhosis and represents the common final pathway leading to death. The short-term mortality rate amounts to 50-90% due to the fact that the cause of hepatocyte injury and the pathway involved in ACLF progression remain elusive. The chronic liver failure (CLIF) Consortium Acute-On-Chronic Liver Failure in Cirrhosis (CANONIC) study indicated that an intense systemic inflammatory r...
ZJU scientists report advances in hepatocellular carcinoma
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2021-02-23
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China is a country with a high incidence of liver cancer. According to the Global Cancer Report, the number of liver cancer cases in China accounts for 46.7% of the total number of cases all over the world. Although appreciable progress in the treatment of HCC has occurred over the past few years, current therapeutic effects are far from satisfactory, and the 5‐year survival rate varies from 14% to 18%. Various kinase inhibitors, such as sorafenib and lenvatinib, come as an enormous boon to live...
Insect transmission of plant single-stranded DNA viruses
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2021-02-19
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Of the approximately 1,200 plant virus species that have been described to date, nearly one-third are single-stranded DNA (ssDNA) viruses, and all are transmitted by insect vectors. It is therefore of immense significance to investigate the insect transmission of plant ssDNA viruses.In January, Prof. WANG Xiaowei from the Zhejiang University College of Agriculture and Biotechnology co-published a review with Stéphane Blanc from the University of Montpellier in the journal Annual Revie...
ZJU scientists reveal transcription activation by a sliding clamp
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2021-02-18
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For decades, transcription of bacteriophage T4 late genes has served as a model system to investigate mechanisms of transcription regulation. The T4 late promoters consist of a -10-like element placed at the position corresponding to the bacterial promoter -10 element. Nevertheless, there is no sequence conservation at the position corresponding to the bacterial promoter -35 element. In recent years, the research team led by Prof. FENG Yu from the Zhejiang University School of Medicine ...
Happy Chinese New Year
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2021-02-12
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To the ZJU community and our international friends, Warmest greetings from the Office of Global Engagement for a Happy Chinese New Year! 2021 is a year of the Chinese zodiac sign “Ox”, starting from Feb. 12th, 2021 and ending on Jan. 31st, 2022. The Ox has long been a symbol of power in Chinese culture. An Ox year is usually considered to be more hopeful and fruitful. May the Ox year bring you happiness and fortune.
Dialogue@ZJU: What are your plans for Spring Festival?
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2021-02-11
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[Message from the Editor: Spring Festival, also known as Chinese Lunar New Year, is an important occasion for the family reunion, and falls on Feb 12 this year. But due to the pandemic prevention, some students have chosen to stay put during the holiday. Some of them share their holiday plans with us.] Emaithy Samudio, Panama, an undergraduate student at the ZJU Ocean College“I have been in China since 2018 and moved to Hangzhou in 2019. I personally found Hangzhou a great city. It’s...