Decoding personal biotic and abiotic airborne exposome
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2021-02-08
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Human diseases are caused by the interplay between intrinsic molecular dynamics and environmental exposures, which can be broadly defined as biological, chemical, physical and even psychological exposures. Abnormal environmental exposures, especially during early life, can lead to a variety of acute and chronic diseases, including cancer, allergy/asthma and autoimmune diseases. The ‘exposome’ was first proposed by Christopher Wild to encompass the totality of human environmental exposures from...
Researchers uncover seed microbiome-mediated disease resistance in rice
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2021-02-07
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Prevalence of seed-borne bacterial diseases poses a severe threat to rice production due to a drastic rise of toxin-producing Burkholderia pathogens, which lead to destructive damage to yield, quality and even resilience of paddy ecosystem. Manipulating disease resistance of the host plant is deemed to be a promising alternative and a more environmentally friendly approach in modern agricultural practices. However, is disease resistance related to the microbiota of the host plant? Is it her...
Zero to one: at the cutting-edge of research
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2021-02-02
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“I attach immense importance to the breakthrough from 0 to 1 and strive relentlessly to pursue innovation and transcendence, which is a driving force for my constant efforts in the cutting-edge research,” said ZHU Yongqun, a recipient of the 16th China Youth Science and Technology Award.ZHU Yongqun has long been committed to research into dangerous disease-inducing bacteria. He has achieved success in unveiling a multitude of “secret weapons” of pathogenic bacteria to overcome immune de...
Scientists identify the structure of adhesion GPCR–G complexes
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2021-01-31
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Recently, the research teams led by ZHANG Yan from the Zhejiang University School of Medicine and Zhejiang Laboratory for Systems & Precision Medicine, SUN Jinpeng from Peking University and Shandong University, and H. Eric Xu from the CAS Shanghai Institute of Materia Medica co-published an article entitled “Structures of glucocorticoid-bound adhesion receptor GPR97-Go complex” in Nature. It is the first time that the structure of adhesion GPCR–G complexes has been identifi...
Scientists create single-cell deep-immune atlas of COVID-19 and discover its immunopathology
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2021-01-30
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As COVID-19 has been raging across the globe in the past year, it has not only constituted tremendous hazards to the safety and well-being of human beings but also incurred immeasurable economic losses. Although most of COVID-19 patients remain asymptomatic or experience only mild symptoms, about 20% suffer overt pneumonia and roughly 5% cases progress to life-threatening Acute Respiratory Distress Syndrome (ARDS) and severe or atypical systemic inflammation. Then how does COVID-19 differ from c...
ZJU4H “Mobile Digital Hospital” ushers in an era of “zero distance” mobile health
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2021-01-29
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Imagine that in the future, a “mobile hospital” bus complete with necessary medical equipment will make it to your neighborhood on time as long as you click the “reservation” on your mobile phone.On January 23, the 5G “Mobile Digital Hospital” built by the Fourth Affiliated Hospital of the Zhejiang University School of Medicine (ZJU4H) was officially launched. It is the first “mobile hospital” to provide medical services in the whole process in Zhejiang Province. Based on a mobile CT car...
Scientists reveal novel mechanism for different parasitic strategies among parasitoid species
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2021-01-28
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The research team led by Prof. CHEN Xuexin from Zhejiang University College of Agriculture and Biotechnology and the research team led by Prof. ZHAN Shuai from Chinese Academy of Sciences co-published a research article entitled “Two novel venom proteins underlie divergent parasitic strategies between a generalist and a specialist parasite” in Nature Communications, revealing the novel mechanism for diverse parasitic strategies among parasitoid species. Parasitoid wasps have been extensively u...
Scientists discover new transmission mechanism of exosome-mediated sorafenib-resistance in hepatocellular carcinoma
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2021-01-27
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Hepatocellular carcinoma (HCC) is the most common primary liver tumor with an increasing global incidence. In 2018, HCC was the sixth most frequently diagnosed cancer and the fourth leading cause of cancer-related death worldwide. Sorafenib is the first FDA-approved targeted therapy for advanced HCC. A previous study showed that sorafenib prolonged the median overall survival (OS) by 2.3−3 months in advanced HCC patients that did not qualify for liver transplantation or resection. However, soraf...
GU Zhen awarded the Felix Franks Biotechnology Medal
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2021-01-26
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On January 15th, the Royal Society of Chemistry (RSC) awarded the Felix Franks Biotechnology Medal to GU Zhen, Qiushi Chair Professor of Zhejiang University and Dean of College of Pharmaceutical Sciences, for his fundamental and technological innovations in the drug delivery field for the treatment of diabetes and cancers. The award ceremony was held at Zhejiang University. Authorized by the RSC Felix Franks Biotechnology Medal Committee, Prof. ZHOU Tianhua, Zhejiang University Vice President, g...
How can a novice teacher make her class engaging?
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2021-01-25
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While in class, her pace is agile and brisk, her eyes are glittering and lively, and her teaching is remarkably logical and meticulous with a string of typical cases. WANG Jiewei, a faculty member at the School of Medicine and a doctor at the First Affiliated Hospital of the Zhejiang University School of Medicine, clinched the grand prize in the finale of Zhejiang University Young Teachers’ Teaching Competition 2020. She still has a vivid memory of her teachers, JI Feng and CHEN ...