ZJU scientists elucidate novel molecular mechanism of MYBPC3-related hypertrophic cardiomyopathy using human iPSC-CM model2022-02-25Hypertrophic cardiomyopathy (HCM), characterized by left ventricular hypertrophy and fibrosis, is the most common monogenic cardiovascular disorder with global distribution and diverse clinical spectrum. The disease prevalence has been estimated at approximately 1:500 in the general population and even higher (1 case per 200) when both clinical and genetic diagnoses are taken into accounts. Patien... READ MORE |
Licensing but not fueling: a metabolic enzyme promotes mitosis beyond metabolism2022-02-23Uncontrolled cell proliferation is a hallmark of cancer. To sustain the ceaseless cell division, cancer cells rewire metabolic pathways in order to provide sufficient nutrient and energy for mitotic progression. Metabolic reprogramming of cancer cells is usually orchestrated by dysregulation of metabolic enzymes. It is generally thought that dysregulated metabolic enzymes contribute to cell cycle ... READ MORE |
Therapeutic potential of opioid agonists in human leukemia2022-02-22Leukemia, the blood cancer, is a group of hematopoietic malignancies. Many types of leukemia are associated with poor outcome. Unfortunately, during the past a few decades, the first-line leukemia therapy has long been traditional chemotherapy with high cytotoxicity and low selectivity, such as the “7+3” strategy, i.e., a combination of cytarabine and doxorubicin. Also, side effects of such inte... READ MORE |
Unraveling correlation of Cd induced metabolic toxicity and diabetes2022-02-17Diabetes has become the leading metabolic disease threatening human health. Meanwhile, the association between exposure to harmful environmental factors and the occurrence of diabetes has always been a hot spot of public health and environmental medicine.A recent study conducted by Dr. ZHOU Zhou’s lab at the Department of Environmental Medicine, the Zhejiang University School of Medicine elu... READ MORE |
Turn brittle mineral into plastic substitute2022-02-16Plastics bring much convenience to human life by virtue of their flexibility, plasticity, lightness and cheapness, but they also pose a considerable threat to the natural environment owing to their non-degradable bonds that lead to “white pollution”. In recent years, an increasing number of researchers have started to seek new “plastics” as an alternative to traditional petroleum-based plastic... READ MORE |
Dialogue@ZJU: With Prof. WEN Wu from the International Campus2022-02-15【Message from the editor: In the previous issues, Dr. SHAO Fangwei and Dr. LIU Zuozhu from ZJUI, and Dr. CHEN Di from ZJE shared their research and teaching at the International Campus. Today, let’s meet Prof. WEN Wu, who joined the Zhejiang University International Business School (ZIBS) as a full-time professor in 2020. He is also a doctoral supervisor of the College o... READ MORE |
Solar housing project structured by ZJUers lands in the Winter Olympic City Zhangjiakou2022-02-12What comes to you when talking about the 2022 Winter Olympics? Fast and fierce actions on the slopes? The cute panda mascot Bing Dwen Dwen? The world has gone warm over the Games since its opening. Want to know how ZJUers contributed to the Games? Let’s turn the spotlight on the Solar House, a Demonstration Project in the host city Zhangjiakou jointly designed and built by an international team, ... READ MORE |
Genetic basis for tissue-specific DNA methylation patterns in plants2022-02-11How does a cell develop into various types of tissues and organs with the same set of genome? Epigenetic modification patterns play a vital role in these processing. DNA methylation, a type of stably inheritable epigenetic modification, which is ubiquitous and conserved in both animals and plants, are essential for gene regulation, transposon silencing and gene imprinting. However, how DNA methyla... READ MORE |
ZJU develops cool technology for Beijing 2022 Winter Olympics2022-02-10Surfing and snowboarding have a lot in common in speed, jumping and spinning. Scientific research also reveals that their actual mechanism is also very similar.Based on these similarities, the Center for Chinese Water Sports Development at Zhejiang University, in partnership with Zhejiang University’s Power Machinery & Vehicular Engineering Institute and Hangzhou Dianzi University, devel... READ MORE |
ZJU scientists contribute their part to green and clean Winter Olympics (II)2022-02-09[Editor’s Note: the Beijing 2022 Winter Olympics was officially opened on February 4. In addition to the crystal white world of ice and snow, the Beijing 2022 is featured by another bright color—green, the symbol of environmental protection. The Games embodies the concept of “greenness” in every dimension, such as ecology, buildings and transportation. This is Part II of a two-part story, showc... READ MORE |
ZJU scientists contribute their part to green and clean Winter Olympics (I)2022-02-08[Editor’s Note: the Beijing 2022 Winter Olympics was officially opened on February 4. In addition to the crystal white world of ice and snow, the Beijing 2022 is featured by another bright color—green, the symbol of environmental protection. The Games embodies the concept of “greenness” in every dimension, such as ecology, buildings and transportation. This is the first installment of a two-par... READ MORE |
Scientists identify HMCES as a novel therapeutic target against leukemia2022-02-06Long-term hematopoietic stem cells (LT-HSCs) generate and maintain lifelong blood cell production through their self-renewal and multi-lineage capacity. In the steady state, this rare population of adult stem cells is quiescent, resulting in decreased reactive oxygen species (ROS) and thereby preserving genome integrity. Driving the quiescent HSCs into cycling due to physiological stress such as i... READ MORE |
Scientists craft a new world with an ultra-fast laser “burin”2022-02-03Laser is dubbed as “the fastest burin”, “the most precise ruler” and “the brightest light”. Since the invention of the first laser in the early 1960s, it has been widely used in various aspects of our lives. Laser is recognized as one of the four greatest human inventions in the 20th century. Usually, it can be divided into two types: continuous laser and pulsed laser. In the 1980s, sci... READ MORE |
The story behind the cool and dazzling “Ice Ribbon”2022-02-02The 2022 Beijing Olympic Winter Games will kick off in several days. As the only major new indoor venue, the National Speed Skating Oval—dubbed the “Ice Ribbon”—has dazzled the world with its impressive “China Solution”. Prof. LUO Yaozhi, Prof. DENG Hua and Prof. YUAN Xingfei from the Zhejiang University College of Civil Engineering and Architecture contribute their wisdom to th... READ MORE |