Safeguarding Germline Immortality RNA Biology Series 1

Speaker: Dónal O'Carroll

Venue: Lecture Hall 205, Comprehensive Building of the School of Medicine, Zijingang Campus

Abstract: The germline is the immortal lineage,the cells that transcend generations and initiate the cycle of life.The mammalian germline is subject to major and essential epigenetic reprogramming.Processes that ensure germ cell development,epigenetic integrity, genomic stability and reproductive lifespan are essential for the long-term health and success of a species, or society in a human context. Our research helps understand the basis of infertility and diseases that arise by germline mutation or epimutation.