The Multidimensional Spatial-Omics Approach from Genomics to Functional Insights

Speaker: Bo Tao

Venue: 2A-203, ZJE Building, Haining Campus

Abstract: Understanding the intricate cellular architecture and molecular signaling within complex disease microenvironments remains a major challenge, limited by technological bottlenecks. This talk will introduce a suite of originally developed, multidimensional spatial-omics technologies that break through these barriers. These tools, including Patho-DBiT and epi-Patho-DBiT, are uniquely compatible with clinical FFPE tissue samples, enabling unprecedented analysis of genomics, epigenomics, and proteomics within a preserved spatial context. We have pioneered the application of these methods to perform in-depth dissections of both atherosclerosis and the tumor microenvironment. This presentation will demonstrate how our spatial approach can directly link molecular data to biological function.