Under the national innovation driven development strategy and "Made in China 2025" Initiave, the need for development of novel biotechnology and novel drugs is urgent. In order to promote the development of biopharmaceutical industry in China, Zhejiang University decided to create internal multidisciplinary collaboration. College of Pharmaceutical Sciences, School of Medicine, College of Life Sciences, College of Chemical and Biological Engineering and Institute of Translational Medicine thus set up a scientific alliance of antibody-based novel drug research and industrialization.

The Alliance aims to serve the construction of pharmaceutical science and novel biotechnology, the integration of internal resources, the establishment of collaborative innovation and the promotion of resource sharing in China, and especially to work with Chinese pharmaceutical industry to accelerate the transformation of scientific and technological achievements.

Antibody-Based Novel Drug Research And Industrialization.docx

Brain science is a new interdisciplinary research field of neural biology, information science, cognitive science, computer science, etc. It has become an important research frontier of natural science in 21^st century, and is promoted to the national strategic level by the government, as China will start the investment in brain projects in the scale of tens of billions yuan.

The Neural Science Research Institute, the Affiliated Hospital of School of Medicine, Qiushi Academy for Advanced Studies, College of Biomedical Engineering and Instrument Science, College of Optical Science and Engineering, College of Computer Science and Technology, College of Information and Electronic Engineering, combine their strengths on the brain science and establish the Alliance.

Brain Sciences.docx

Breeding of crops and animals is a high-tech industry depended on multiple basic disciplines like genetics, genomics and molecular biology, and on other agricultural sciences such as agronomy, plant protection and soil science. The development and application of biotechnology, intelligent technology, information technology and big data technology have greatly promoted the advance of breeding industry. Zhejiang University has a wide range of scientific disciplines related to crop and animal breeding, such as strong agricultural sciences, biotechnology, as well as information technology and big data technology, and hence it owes obvious comparative advantages.

To better integrate the research platforms and expert resources, and to take advantage of the comprehensive nature of the University, the Alliance for Breeding of Rice and Major Economic Crops was established in 2016, which aims to enhance ZJU's capability of and contribution to breeding, cultivate high-level talents, foster the advance of relevant scientific disciplines, and promote the progress of seed industry.

Breeding of Rice and Major Economic Crops.docx

Coal is an important source of energy and a precious resource. The Alliance develops technologies for poly-generation of heat, oil and gas from coal, and ultra-low emission of pollutants from coal combustion power plant, which contribute to the national strategic requirement for clean coal-fired technology while protecting the atmosphere. The Alliance aims to be an international first-class technological innovation platform in the field of coal power, focusing on major issues in clean power generation from coal and developing innovative mechanism for promoting university-industry collaboration.

The Alliance was accredited by the Ministry of Education and the Ministry of Finance in October 2014.

Clean Coal Power Generation and Resource Utilization.docx

"One Belt and One Road" Initiative is a bridge for China's establishment and development of cooperative partnerships with the countries and regions along the Belt and Road, which makes it a major initiative for international cooperation in the new era. Under the guidance of the leading office of “One Belt and One Road” Construction, Technological Alliance of research on “One Belt and One Road” Initiative Development & Opening-up aims to satisfy national needs and address major theoretical and practical issues in the development of“One Belt and One Road” Initiative.

Supported by the Research Center of Regional Coordination Development of Zhejiang University and China Academy of West Region Development, the Alliance integrates the interdisciplinary forces of the University, including economics, public administration, education, computer science, environmental resources, biomedicine and geography as well as the innovative strength and advantageous resources of state-level research institutes, e.g. Institute of Geographic Sciences and Natural Resources Research of Chinese Academy of Sciences, China Institute of Macroeconomics, Development Research Center of the State Council and some universities, to build an open, interdisciplinary research alliance.

The Alliance conducts forward-looking, well-targeted research for the organic convergence of basic theories, applied theories and decision-making and consulting researches. In June 2017, the Research Center of Regional Coordination Development of Zhejiang University was recognized by the Publicity Department of the CPC Central Committee as a national top think tank construction and development unit.

The Alliance, supported by the““One Belt and One Road” Initiative trade and investment database and Maritime Silk Road shipping big data, gives full play to the multidisciplinary advantages of ZJU in building a holistic system by integrating talent cultivation, scientific research, social services, cultural exchanges and innovation for original and representative academic achievements. Therefore, the Alliance has achieved a lot in the five aspects, i.e., discipline development, consultation, forward-looking research, data platform and talent team building so as to better serve the Initiative.

Development and Opening-up Research of One Belt and one Road_Initiative.docx

Water pollution and air pollution are the major environmental issues in our country. Therefore, the State Council has issued the Action Plan for Prevention and Control of Water Pollution and Air Pollution.

To serve the national needs, the Research Alliance of Drinking Water Safety and Air Pollution Control was established through the integration of multiple disciplines. It strives to construct an integrated system of pollution control and security technology for drinking water from source to tap, as well as a key technology system for high-efficiency control of air pollution sources, indoor air purification, and health risk assessment of pollution.

The Alliance aims to undertake national major scientific research tasks, make prominent scientific research achievements, cultivate leading talents and academic backbone, and build a high-level scientific research team so as to build itself into a research alliance with significant international influence.

Drinking Water Safety and Air Pollution Control.docx

Based on agricultural products, food industry is fundamental to a country with increasing importance, which ensures the continuous increase of agricultural production, the improvement on the quality of life, and the promotion of rural industries. Food manufacturing is the key to healthy China. Since the 11th Five-year Plan, China has formulated and implemented a special program for agricultural products processing, and a batch of major agricultural product processing projects have been successively implemented in various places.

Food science covers the entire industrial chain, including field cultivation, harvesting, post-harvest logistics, processing and utilization, food nutrition and digestion, etc., which has obvious cross-trait. Food-related disciplines of Zhejiang University, including horticulture, food and pharmacy, were graded “A” by the Ministry of Education, occupying a leading position in China. Thus solid foundation is laid for the implementation of interdisciplinary researches.

The implementation of this project will support the development of agricultural products processing and logistics, combine the strength of related discipline, build up platform of food manufacturing, logistics technology and product development, and help establish ZJU's dominant position in this field.

Food Manufacturing and Logistics.docx

Soil to the Earth is like skin to a man. It is the survival basis and essential wealth to human, which not only supports food production, but also supplys clean groundwater and protect biodiversity. However, in the past 20-30 years, with the rapid development of industrialization and economic growth, natural resources have been exploited. Large quantities of untreated sewage have been directly irrigated. Solid waste was discarded everywhere or simply land-filled. Unreasonable application of chemical fertilizers and pesticides resulted in serious soil pollution and big challenge for food safety and human health in China.

In 2014, the Ministry of Environmental Protection and the Ministry of Land and Resources jointly issued the National Soil Pollution Survey Bulletin. The survey shows that the condition of soil environment in China, especially the cultivated land area, isn't optimistic currently. The total pollution points of national soil exceeded 16.1%, cultivated land exceeded the standard rate, which is as high as 19.4%, and the area of medium and heavy polluted arable land increased up to 3.3 million hectares, mainly suffering from the pollution of heavy metals and organic pollutants. It is urgent to implement the economic, efficient and feasible pollution remediation technology.

In order to deal with the problem of soil pollution, Chinese government has already launched “the Action Plan for Soil Pollution Prevention and Control” in 2016. Meanwhile, the government is currently promoting legislation on prevention and control of soil pollution. Under such circumstances, Zhejiang University established a Science and Technology Alliance for Key Technologies Research in Contaminated Soil Remediation to promote soil pollution control and remediation from laboratory to industrialization.

Key Technologies Research in Contaminated Soil Remediation.docx

Research Alliance of Medical Device (Technical Innovation) is led by Sir Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine and co-built by College of Computer Science and Technology, Department of Polymer Science and Engineering, School of Mechanical Engineering, College of Optical Science and Engineering, Institute of Translational Medicine, College of Biomedical Engineering and Instrument Science of Zhejiang University. It focuses on minimally invasive medicine research, clinical technology development and medical device development. Its main function is to provide theoretical support for the technological development of minimally invasive medicine, and to translate the innovative ideas in minimally invasive clinical practice into technical results. Through original innovation, integrated innovation, absorption of advanced foreign technology,the Alliance continues to develop minimally invasive device and promote the localization of medical device.

Medical Device (Technical Innovation).docx

Chronic non-infectious diseases are among the most concerned diseases that threaten the health of Chinese people. According to the Report on Nutrition and Chronic Diseases of Chinese Residents (2015) issued by the State Council, the mortality of chronic diseases in China was 533/10 million, and chronic non-infectious diseases accounted for 86.6% of the total deaths in 2012. Among them, cardiovascular diseases, malignant tumors, chronic obstructive pulmonary disease (COPD), diabetes and neuropsychiatric diseases are the main causes of death, and the incidences are increasing rapidly. The proportion of these major diseases increased from 65.5% in 1990 to 79.4% in 2010. More seriously, due to the change of life style and the aging of the population, it is expected that the morbidity in China will continue to grow in the next 10-15 years.

The overall goal of this project is to solve the key problems in treating cardiovascular diseases, malignant tumors, COPD, diabetes and neuropsychiatric disorders and other serious major chronic diseases that threaten people's health through large sample, population-based multicenter clinical trials.

We aim to set up public platforms, establish and perfect the research system and innovation network to make significant breakthroughs in the prevention and control of major chronic diseases. New technologies, molecular markers and prevention guidelines will be identified and developed.

Four programs are included in this project: 

- Development of new technology and scheme on cervical cancer screening and intervention;

- Study on correlations with nutrition and influence factors in children and adolescents with diabetes;

- Identification of early diagnosis biomarkers and comprehensive diagnosis index system in Parkinson's disease;

- Tumor therapy by targeting tumor lactate anions and hydrogen ions.

Prevention and Control of Major Chronic Non-Infectious Diseases.docx

Zhejiang University is one of the pioneering Chinese universities in the research on robotics and intelligent machines. In early 1980s, ZJU carried out researches on the industrial robots. The earliest domestic "six degree of freedom series hydraulic mechanical arm" was manufactured in that period.

In the field of robotics and intelligent equipments, ZJU has already been equipped with good research and technology foundation. In order to facilitate further integration of the preponderant research power intramural, and also to promote our research level through the multidisciplinary cooperation, the Research Alliance of Robotics and Intelligent Machines has been established.

The Alliance is led by Professor YANG Huayong, member of Chinese Academy of Engineering. It has integrated five faculties, namely science, engineering, information, agriculture and medicine, and more than 30 research groups. The Alliance concentrates on the international frontier of robotics and intelligent machines. Meanwhile, aiming at 3-5 advantageous research directions during the “Thirteenth Five-Year Plan”and achieving an advanced level internationally, the Alliance carries out both basic research and key technological research. In addition, it will also manufacture a batch of robotics and intelligent machines or products, aiming to make Zhejiang University an essential research and development hub.

Robotics and Intelligent Machines.docx

The goal of our alliance is to investigate synthetic control of excited states, physical-chemical properties and applications of colloidal quantum dots (QDs).

Colloidal quantum dots (QDs) are a unique class of fluorescent materials with quantum confinement effects. Owning to their outstanding optical properties, such as broad-band absorption, narrow and tunable emission, high photoluminescence quantum yield and high photo-chemical stability, QDs have great potential in the fields of biomedical imaging and photoelectric devices. Their optical and electrical properties can be continuously tuned by size and composition.

Besides, compared with the conjugated organic/polymer light-emitting materials and fluorescent protein, QDs have superior advantages like thermal, optical, and chemical stability, small excited state relaxation energy, long photoluminescence life and high color purity. Compared with the phosphor and other inorganic solid luminescence materials, they have other advantages including superior color purity, flexible synthetic chemistry and solution processability. Therefore, QDs are expected to be understanding materials for light-emitting diode and other applications.

We aim to establish an international leading research alliance in the field of QDs, focusing on the basic scientific problems-the excited states of QDs with scopes on synthesis chemistry, ligand chemistry, spectroscopy and the related applications.

Science and Technology for Novel & High-Performance Materials.docx

China has made remarkable achievements in the field of stem cell and regenerative medicine in recent years. Zhejiang University has more than 100 principal investigators (PI) working on stem cell biology, developmental biology, tissue engineering and regenerative medicine. Obviously, the promise of stem cells cannot be fulfilled by one lab, and collaborationis the trend of modern research. Research Alliance on Stem Cell and Translational Medicine was formally established in April 18, 2016.

Stem Cell and translational Medicine.docx

Chemical industry is always one of dominant factors that significantly affects the progress of national economy and social development. So far, the output value of chemical industry has accounted for about 16% of GDP in China. Modern chemical products have greatly enriched our material life and improved the quality of life. They also play an important role in controlling the disease, increasing the crop yield and improving technologies of national defense, spaceflights as well as information.

However, high-speed development of modern chemical industry has also resulted in many problems related to the resources and environment worldwide, including the growing scarcity of resources on the earth, high price of oil and apparent degradation of ecological environment. In China, problems related to high energy consumption and waste discharge in chemical industry are severe. The energy consumption of unit output value in our country is 3-8 times of that in developed countries, and the amount of carbon emission ranks the 1^st in the world. 

Therefore, developing technologies and equipments to improve traditional chemical processes, save energy and reduce emission based on the concept of sustainable development is necessary and urgent at present. Meanwhile, national planning and deployment in the fields of energy (energy conservation), water and mineral resources (high efficiency of mineral resources), environment (pollution control and circular utilization of waste), manufacturing industry (green and automation of process industry, development of raw materials), public security, advanced manufacturing technologies (life prediction of major production facilities), advanced energy technologies (hydrogen energy and fuel cell) and so on not only bring new missions to research on chemical engineering and chemical process equipment, but also give new opportunities to the related research areas.

Technologies and Equipment for Chemical Process Intensification.docx